In Re Rezulin Products Liability Litigation

OPINION

KAPLAN, District Judge.

Table of Contents

I. The Legal Backdrop and. the Positions of the Parties.401

II. Proceedings on the Motion.402

III. Scientific Background.

A. Relevant Physiology.

1. Cells .

2. The Liver.

3. Mechanisms of Cell Death.

B. Drugs, Toxicity to the Liver, and Rezulin

C. Patient Population.

D. Evidence of Causation in Medicine.

IV.The Proposed Testimony.

A. The Experts and Their Opinions. Lr*

1. Dr. Smith. Ir**

2. Dr. Reed.

3. Dr. Julie.

4. Dr. Day.

5. Dr. Bonkovsky.

6. Summary.

B. The Science upon Which the Experts Rely. H

1. Early Links in the Proposed Causal Chain: The Claim that…