Grosheintz‐Fischer‐Reissert Aldehyde Synthesis

The synthesis of aldehyde involving the formation of 1‐acyl‐2‐cyano‐1,2‐dihydroquinoline derivatives from acyl chlorides, quinoline, and potassium cyanide and the subsequent hydrolysis of said dihydroquinoline derivatives under acidic conditions to produce quinaldic acid and aldehydes is generally referred to as Grosheintz–Fischer–Reissert aldehyde synthesis. The modification from Grosheintz and Fischer using hydrogen cyanide and 2 eq. quinoline in absolute benzene is also adaptable for aliphatic acid chloride. The reaction has been found superior to the Rosenmund reduction.