Abstract
⇒ Deep brain stimulation has been used for neurological disorders globally since the 1980s ⇒ The benefits and harms associated with deep brain stimulation for Parkinson's disease have not previously been systematically assessed WHAT THIS STUDY ADDS ⇒ Deep brain stimulation with antiparkinsonian drug treatment seemed to increase the risk of serious adverse events compared with antiparkinsonian drug treatment only ⇒ Preliminary results indicated that deep brain stimulation might reduce symptoms specific to Parkinson's disease, but the beneficial effects are uncertain because of methodological limitations HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE, OR POLICY ⇒ Randomised trials assessing patient important outcomes, including adverse effects, are urgently needed ⇒ Observational studies could supplement randomised trials, especially for assessing rare adverse events ABSTRACT OBJECTIVE To assess the benefits and harms of deep brain stimulation for Parkinson's disease. DESIGN Systematic review with meta-analysis and trial sequential analysis.
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