Organ chips and uses thereof
President and Fellows of Harvard College
Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
1ClaimsFirst of 7
- 1
A method comprising: (a) contacting muscle cells, organ-specific parenchymal cells that are a different cell type from the muscle cells, or a combination thereof, with at least one active agent for a period of time, wherein the organ-specific parenchymal cells and the muscle cells are cultured independently in at least two different organ chips, wherein said at least two different organ chips are each independently configured according to either a first organ chip or a second organ chip, and…
2Description
This invention was made with government support under U01 NS073474-01 from the National Institutes of Health and Food and Drug Administration, and W911NF-12-2-0036 from the Defense Advanced Research Projects Agency. The government has certain rights in the invention.