Patent
Peptide enzyme inhibitors of angiotensin I
E. R. Squibb & Sons, Inc.
US 3,973,006GrantedGranted Aug 3, 1976Filed Feb 21, 1975
Ester and amides of the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro have been found to inhibit the hypertensive effect of angiotensin I.
Claims
6
1 independent claim
Filing to grant
1.4 years
Pendency
1ClaimsFirst of 6
- 1
A peptide having the formula Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OR or Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-NH.sub.2 wherein R is an alkyl group containing 1 to 10 carbons.
2Description
Background of the Invention
The action of the enzyme renin on renin substrate, a pseudoglobulin in blood plasma, produces a polypeptide angiotensin I, also known as hypertensin I. The latter is converted by an enzyme to angiotensin II, also known as hypertensin II or angiotonin. Angiotensin II is an active pressor substance which is present in the plasma of individuals with hypertension in quantities sufficient to maintain…