Compounds and method for alleviating angiotensin related hypertension
E. R. Squibb & Sons, Inc.
A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
1ClaimsFirst of 11
- 1
A method for alleviating angiotensin related hypertension in hypertensive mammals which comprises administering an effective dose of an angiotensin converting enzyme inhibitor having the formula ##STR8## or salt thereof, wherein R.sub.1 is hydrogen, lower alkyl, phenyllower alkylene, hydroxy-lower alkylene, hydroxyphenyl-lower alkylene or guanidinolower alkylene; R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, lower alkyl or phenyl-lower alkylene; R.sub.5 is hydrogen, lower alkanoyl, benzoyl or…
2Description
Angiotensin II is a powerful vasoconstrictor agent that has been implicated as the main causative agent in the etiology of renovascular hypertension.