Engineered polymerases with reduced sequence-specific errors (US Patent 12006518)

Patent number: 12006518 Kind code: B2 Granted: 2024-06-11 Filed: 2023-01-27 Inventors: Jendrik Hentschel (San Diego, CA, US); Tyler Lopez (Winchester, CA, US); Michael Klein (Encinitas, CA, US); Virginia Saade (San Diego, CA, US); Matthew Kellinger (San Diego, CA, US); Mark Ambroso (Escondido, CA, US) Assignees: ELEMENT BIOSCIENCES, INC. (San Diego, CA, US) CPC: C12N 9/1252

Abstract

Provided herein are engineered variants of archaeal polymerases that exhibit exonuclease-minus activity, enhanced