Process for the deprotection of protected thiols (US Patent 6906171)

Patent number: 6906171 Kind code: B2 Granted: 2005-06-14 Filed: 2002-01-18 Inventors: Alan Cuthbertson (Oslo, NO) Assignees: Amersham Health AS (Oslo, NO)

Abstract

The synthesis of peptides comprising disulphide bridges is challenging since it is difficult to ensure that the correct cysteine residues combine to form the desired disulphide bridges. The present invention describes novel protection techniques useful in the preparation of peptides. Described is a process for the deprotection of an Acm-, MBzl- and/or