Process for preparing certain azapirones (US Patent 5521313)

Patent number: 5521313 Granted: 1996-05-28 Filed: 1994-05-05 Inventors: Gary D. Madding (Evansville, IN, US) Assignees: Bristol-Myers Squibb Company (New York, NY, US)

Abstract

An improved process for preparation of certain useful azapirones, e.g. buspirone, gepirone, tandospirone, etc., comprises the reaction of a novel spiroquaternary piperazinium hydroxide with an appropriate imide to form imidate salts which are then converted to the azapirone by heating. This process is suitable for large scale adaptation and has