Patent
Process for the preparation of mixed anhydrides (US Patent 6489479)
Hoffman-La Roche Inc. · Granted Dec 3, 2002 · Filed Jul 22, 1999
Patent number: 6489479 Kind code: B1 Granted: 2002-12-03 Filed: 1999-07-22 Inventors: Martin Karpf (Reinach, CH); René Trussardi (Birsfelden, CH) Assignees: Hoffman-La Roche Inc. (Nutley, NJ)
Abstract
The present invention is concerned with an improved process for the manufacture of mixed anhydrides. The process comprises adding an adjuvant base to a mixture of acid and reactive acid derivative. It is especially suitable for use in the synthesis of peptides and/or for the manufacture of pharmaceutically active
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