Engineering organisms resistant to viruses and horizontally transferred genetic elements (US Patent 11149280)

Patent number: 11149280 Kind code: B2 Granted: 2021-10-19 Filed: 2020-11-30 Inventors: Farren Isaacs (New Haven, CT, US); Natalie Ma (New Haven, CT, US); Jesse Rinehart (West Haven, CT, US); Colin Hemez (New Haven, CT, US) Assignees: YALE UNIVERSITY (New Haven, CT, US) CPC: C12N 15/102; C12N 15/1024; C12N 15/70; C12N 9/93; C12Y 601/01

Abstract

Organisms resistant to horizontal gene transfer (HGT), and compositions and methods of use thereof are provided. The organisms are